Performance of Enlist One (2,4-D) and Liberty (Glufosinate) Applied in Mixture or Sequentially for Weed Control in Soybean

Updated March 27, 2026
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Eric Jones

Assistant Professor and SDSU Extension Weed Management Specialist

Additional Authors: Philip Rozeboom

Written collaboratively by Eric Jones, Jill Alms, David Vos and Philip Rozeboom. 

Herbicides are recommended to be applied in mixtures to increase application efficiency, spectrum of weed control, and reduce selection pressure on resistant biotypes. 2,4-D (Enlist One; Herbicide Group 4) and glufosinate (Liberty; Herbicide Group 10) are often applied in mixture to additively manage various weed species and the commercial availability of herbicide-tolerant soybean varieties. 

Field experiments were conducted in 2023 and 2024 near Beresford (SDSU Southeast Research Farm) and South Shore (SDSU Northeast Research Farm), SD, for a total of four site-years to look at performance results of Enlist One and Liberty weed control in soybean when applied in mixture or sequentially. 

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